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Serum lipoprotein(a) and risk of periprocedural myocardial injury in patients undergoing percutaneous coronary intervention

Clinical Cardiology Dec 20, 2020

Huang Z, Shui X, Ling Y, et al. - Among patients with coronary heart disease (CHD), it was inquired whether serum lipoprotein(a) [Lp(a)] concentrations were associated with the risk of periprocedural myocardial injury after percutaneous coronary intervention (PCI). Participants included 528 nonacute myocardial infarction (AMI) CHD patients who were successfully treated with PCI. Prior to PCI, fasting serum lipids including Lp(a) were assessed. Prior to PCI and 24 h post-PCI, high‐sensitivity cardiac troponin I (hs‐cTnI) was evaluated. As a continuous variable, raised Lp(a) concentrations were shown to be independently related to the risk of increased postprocedural cTnI values above 1 × upper limit of normal (ULN), 5 × ULN, 10 × ULN and 15 × ULN, in multivariate analyses adjusting for conventional covariates and other serum lipids. As a categorical variable, Lp(a) > 300 mg/L was identified as an independent risk factor of postprocedural TnI ≥1 × ULN, ≥ 5 × ULN and ≥ 10 × ULN. Findings revealed that increased preprocedural Lp(a) concentrations were related to the risk of PCI‐associated myocardial injury in non‐AMI CHD patients.

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