Zhang X, et al. - In 12,549 hypertensive patients with eGFR ≥60ml/min/1.73m² from the renal sub-study of the China Stroke Primary Prevention Trial, researchers assessed the risk of rapid renal function decline in relation to different lipids parameters, including triglycerides (TG), high density lipoprotein cholesterol (HDL-C), the TG to HDL-C (TG:HDL-C) ratio, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). They also investigated any factors that might modify effects in general hypertensive patients with normal renal function. Findings revealed a remarkably higher risk of rapid renal function decline in participants with higher TG (≥150 vs <150mg/dL, 7.7% vs 5.5%), higher TG:HDL-C ratio [≥2.7 (median) vs <2.7, 7.7% vs 5.0%), lower TC (≥200 vs <200mg/dL, 6.0% vs 7.0%) or lower LDL-C levels (≥130 vs <130mg/dL, 6.1% vs 7.0%). Overall, in hypertensive adults with normal renal function, the independent risk factors for rapid renal function decline were higher TG and TG:HDL-C ratio.