Song YR, Kim JK, Lee HS, et al. - Given that raised oxidative stress in end-stage renal disease is considered as one of the essential mechanisms in the atherosclerosis and muscle wasting, but researches assessing the clinical value of oxidative stress via direct measurement of these markers as well as its link with volume status and sarcopenia are limited, so, researchers measured serum protein carbonyl levels as a biomarker of oxidative stress in stable hemodialysis (HD) patients studied in this follow-up cross-sectional analysis. They identified a correlation of serum protein carbonyl levels with serum levels of albumin, prealbumin and transferrin, hydration status and low handgrip strength. In multivariate analysis, independent determinants of all-cause death were: serum levels of protein carbonyl, albumin, prealbumin, overhydration and sarcopenia. Overall, findings revealed a significant correlation of serum protein carbonyl with overhydration, nutritional status as well as sarcopenia, and showed that serum protein carbonyl could serve as a novel predictor of death in patients receiving HD.