Hooshmand B, et al. - In this longitudinal population-based study involving older Finnish adults, researchers investigated the association of serum glucose, insulin, and insulin resistance with cognitive functioning at baseline and at 7 years follow-up. The investigators collected, measured, and analyzed glucose and insulin samples from 269 dementia-free individuals (aged 65-79 years) from the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study. They used the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) to estimate insulin resistance. Study participants were assessed for global cognition, episodic memory, executive functioning, verbal functioning, and psychomotor speed at baseline and 7 years later. There were no associations of insulin resistance with cognitive functioning in the multivariable-adjusted linear regression models. They noted an association of raised serum insulin levels with lower scores on global cognition and poorer performance in psychomotor speed. Overall, serum insulin and insulin resistance may be predictors of cognitive function 7 years later in older, dementia-free adults.