Tseng TC, Liu CJ, Yang WT, et al. - This study was sought to evaluate if a high hepatitis B core‐related antigen (HBcrAg) level is associated with an increased risk of cirrhosis, particularly in patients with intermediate viral load (HBV DNA 2000‐19 999 IU/mL) due to their moderate risk of disease progression. Researchers included 1,673 treatment‐naïve, non‐cirrhotic patients with negative hepatitis B e antigen (HBeAg) and alanine aminotransferase (ALT) level < 40 U/L at baseline. In all patients, they investigated the association between baseline levels of HBcrAg and cirrhosis development and whether a higher HBcrAg level (< 10 vs ≥10 KU/mL) was correlated with an elevated risk of disease progression in those with intermediate viral load. The data exhibited that higher HBcrAg levels are associated with an increased risk of cirrhosis in HBeAg‐negative patients with normal ALT levels. The findings indicated that HBcrAg < 10 KU/mL characterizes a low‐risk group for disease progression, among those with intermediate viral load.