Huang Y, et al. - In a Chinese Han population, researchers ascertained if serum haptoglobin (Hp) levels play a role in the development and progression of diabetic kidney disease (DKD) in patients with T2DM. Two hundred thirty-three candidates who had suffered from T2DM for more than 10 years were recruited, involving 118 patients with DKD (case) and 115 patients without DKD (control). Investigators found that serum Hp levels were significantly higher in the case group than the control. The serum Hp level has been significantly positively correlated with both logarithmically transformed (log-transformed) serum creatinine and albuminuria levels and has been negatively related to the log-transformed estimated glomerular filtration rate. After multiple linear regression analysis, serum Hp levels were significantly associated with serum creatinine levels after adjusting for confounding risk factors. Serum Hp levels can be used for early diagnosis and monitoring of DKD in T2DM patients as a potential biomarker.