Bostom A, et al. - Given that “T50,” shortened transformation time from primary to secondary calciprotein particles might reflect deranged mineral metabolism predisposing to vascular calcification and cardiovascular disease (CVD), researchers used the Folic Acid For Vascular Outcome Prevention In Transplantation (FAVORIT) cohort to analyze a randomly selected subcohort of patients and all individual cases who developed CVD to determine the association of T50 and fetuin-A with the risk of CVD in kidney transplant recipients. Findings revealed that in a large, multiethnic cohort of long-term kidney transplant recipients (KTRs), shortened T50, and reduced fetuin-A levels were found to be related to a greater risk for CVD outcomes, after adjustment for major CVD risk factors, measures of kidney function and damage, and KTR clinical characteristics and demographics. Increased high sensitivity c-reactive protein was identified to be an effect modifier of these CVD risk links.