Bundy JD, et al. - Given that increased risks for cardiovascular disease events and mortality attributed to coronary artery calcification (CAC) have been reported in patients with chronic kidney disease (CKD), researchers investigated in this prospective cohort study whether a novel serum measure of calcification propensity is related to CAC among patients with CKD stages 2 to 4. This study included subjects from the Chronic Renal Insufficiency Cohort (CRIC) Study with baseline (n = 1,274) and follow-up (n = 780) CAC measurements. Outcomes included CAC prevalence, severity, incidence, and progression. In this study, multivariable-adjusted generalized linear models were used. CAC prevalence was detected in 824 (65%) participants at baseline. Findings revealed an association of higher serum calcification propensity with more severe CAC and CAC progression among patients with CKD stages 2 to 4.