Dobre M, et al. - The association between serum bicarbonate concentration, as a measure of metabolic acidosis, and cognitive function was determined in hypertensive adults with and without CKD enrolled in the Systolic BP Intervention Trial (SPRINT). Five cognitive summary scores (global cognitive function, executive function, memory, attention/concentration, and language) were measured. In a subset who underwent brain magnetic resonance imaging, the models were adjusted for white matter hyperintensity volume, vascular reactivity, and cerebral blood flow. It was found that higher serum bicarbonate levels were independently related to better global cognitive and executive performance in a large cohort of hypertensive adults.