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Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus

BMC Oral Health Apr 16, 2018

Guo LN, et al. - Researchers gauged the ferritin and hepcidin levels in serum and saliva of chronic periodontitis (CP) patients with or without type 2 diabetes mellitus (T2DM). They found iron overload and hepcidin inadequacy in CP with T2DM patients. For body iron load, salivary ferritin could provide a reference.

Methods

  • Experts collected the samples of serum and unstimulated whole saliva from 88 participants, who were categorized into 4 groups based on the presence or absence of CP or T2DM.
  • They recorded the demographics and general health parameters.
  • Authors also recorded the full-mouth clinical periodontal parameters including probing pocket depth, clinical attachment loss, bleeding index, and plaque index.
  • In order to detect ferritin and hepcidin concentrations, respectively, in serum and saliva, chemiluminescence microparticle immunoassay and enzyme-linked immunosorbent assay were used .

Results

  • As per the data, serum ferritin and hepcidin levels in the CP and CP with T2DM groups were higher than the control group (P < 0.05).
  • They noted a linear correlation between serum hepcidin and serum ferritin (P < 0.001).
  • Compared to those in the T2DM and control groups, serum hepcidin/ferritin values in the CP with T2DM group were significantly lower.
  • Findings suggested the salivary ferritin levels in the CP and T2DM groups to be higher than those in the control group (P < 0.05).
  • Salivary ferritin was positively correlated with serum ferritin (P=0.017).
  • Results demonstrated relatively low hepcidin concentrations in the saliva.

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