Guo J, Zeng M, Zhang Y, et al. - Given the oft-occurrence of cardiac valve calcification (CVC) in maintenance hemodialysis (MHD) patients as well as its link with cardiovascular and all-cause mortality, researchers assessed the links between risk factors and extent of CVC and further afforded the treatment target in MHD patients. This study included 145 patients who were on MHD for ≥ 3 months, with average age 50 ± 12 years, and 54.5% being men. The mean global cardiac calcium scoring system (GCCS) was 1.8 ± 2.4. Findings revealed a significant link of serum alkaline phosphatase (ALP) level with CVC in MHD patients. CVC was robustly predicted by serum ALP ≥ 232 U/L. Also, serum ALP ≥ 232 U/L was found to be related to the likelihood of GCCS ≥ 1. Based on the findings, ALP may be a promising interventional target for cardiovascular calcification in MHD patients.