Walther CP, et al. - In this longitudinal evaluation of a population-based community-living cohort from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study, researchers investigated if serum albumin concentrations are related to incident end-stage renal disease (ESRD) independently of urine albumin-to-creatinine ratio (ACR). The cohort included subjects ≥45 years of age at study entry with serum albumin, creatinine, cystatin C, and spot urine ACR measured at the baseline visit. According to findings, a higher risk of incident ESRD was observed in relation to lower serum albumin concentration in community-dwelling US adults. This link was independent of baseline urine ACR, estimated glomerular filtration rate (eGFR) and other ESRD risk factors.