Takegawa R, et al. - In this study consisting of 136 septic patients treated in the ICU (intensive care unit) for > 7 days, researchers assessed the link between nutritional biomarkers, including serum albumin, total protein, total cholesterol, and cholinesterase, and prognosis, retrospectively. They resolved the difference of the statistical weight of each day's data for all 14 consecutive days by using time-dependent Cox proportional hazard regression analysis. The minimum moving values determined from 1 day, 3 days, 7 days, and 14 days of serial data formed the basis of the covariates. They assessed the values of these covariates and ICU survival as outcomes. Findings revealed that the higher risk of death in patients with prolonged sepsis was indicated by the changes in serial data of the nutritional markers. A significant association of daily changes of serum albumin with mortality during the ICU stay was evident.