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Serum 25-hydroxyvitamin-D and nonalcoholic fatty liver disease: Does race/ethnicity matter? Findings from the MESA cohort

Nutrition, Metabolism & Cardiovascular Diseases Dec 04, 2019

El Khoudary SR, Samargandy S, Zeb I, et al. - Given that studies of mainly white participants have revealed a link between low serum 25-hydroxyvitamin D (25(OH)D) and higher nonalcoholic fatty liver disease (NAFLD) risk, and there exist significant racial/ethnic disparities in serum 25(OH)D and NAFLD prevalence questioning extending this link to other racial/ethnic groups, therefore, researchers undertook this cross-sectional study from the Multi-Ethnic Study of Atherosclerosis (MESA) in order to examine if the link between serum 25(OH)D and NAFLD differ by race/ethnicity. There were 3,484 participants (44% male; 38.4% Whites, 27.8% African-Americans, 23.5% Hispanics, and 10.3% Chinese-Americans) in total. Experts concluded that the negative link between serum 25(OH)D and NAFLD in Whites may not be broadly generalizable to other racial/ethnic groups. They found the link of modifiable risk factors including BMI, triglycerides, diabetic status and/or smoking, with the risk of NAFLD in non-white racial/ethnic groups beyond 25(OH)D.
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