Piffer S, et al. - Via performing this retrospective observational study of all pregnant women delivered in maternity units in Trento province, North East Italy, between 2009-2018, researchers investigated the trend over time and the outcomes of serological screening for hepatitis C infection in pregnancy and obstetric and neonatal outcomes. Among a total of 45,493 analyzed pregnant women (75.5% Italians and 24.5% foreigners), serological HCV screening coverage of about 99.4% was recorded. The mean overall seroprevalence of 3.9% was observed in these pregnant women. Mothers coming from Asian countries had the highest seroprevalence. Observations suggest an excess risk for intrahepatic cholestasis and gestational diabetes among HCV positive mothers compared with HCV negative mothers. A statistically significant increase in preterm births, low birth weight, elective Caesarean births, hospitalisation at birth and bottle- or mixed-feeding vs breast-only feeding was highlighted by the neonatal outcomes examined. Differences in obstetric and neonatal outcomes were observed in relation to the HCV positive subgroup of the mother defined in particular by exposure to smoke and/or opioids. The presence of HCV can account only for a part of the maternal and neonatal outcomes examined.