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Serial C-reactive protein measurements in newborn infants without evidence of early-onset infection

Neonatology May 25, 2019

Macallister K, et al. - In the first days of life, researchers described postnatal C-reactive protein (CRP) responses in asymptomatic infants with a negative blood culture through the collection of data from infants who had a blood culture taken at < 72 h in a UK maternity hospital. For this investigation, they recorded all CRP values and their time from birth. They excluded infants with signs of infection, positive blood culture, or major congenital anomalies. A total of 219 babies have been screened during the study period. Seventy-three infants were analyzed after exclusions. A rise in CRP has been demonstrated without evidence of infection in term and preterm infants. In term infants, this rise was the greatest. CRP values should be interpreted in the context of the clinical condition of an infant and should not be used alone to guide clinical decision making.
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