Solé C, Ma AT, Solà E, et al. - The findings are highly suggestive of a lack of significant tubular injury in acute kidney injury due to hepatorenal syndrome (AKI-HRS) and may be useful in the clinical decision between combined liver-kidney transplantation or liver transplantation alone in patients with cirrhosis and AKI transplant candidates.

• The authors conducted repeated measurements of biomarkers of tubular injury during a 14-day period in 60 individuals with cirrhosis and AKI (34 with AKI-HRS meeting the classical definition of type 1 HRS and 26 with AKI due to acute tubular necrosis, AKI-ATN).

• Nineteen of the 34 patients had resolved AKI-HRS, whereas the others had persistent AKI-HRS.

• Short-term mortality was related to the persistence of AKI-HRS.

• Throughout the 14-day period, there were no significant variations in urinary NGAL or IL-18 levels between patients with resolution and those with persistent AKI-HRS.

• When compared with AKI-ATN, biomarker levels in AKI-HRS were much lower, even if persistent.