Raputova J, et al. - In this study, researchers sought to delineate the sensory phenotypes of patients with painful and painless diabetic neuropathy and to investigate demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined distal symmetrical sensory-motor polyneuropathy (DSPN) subjects. Findings revealed that neuropathic pain (NeuP) presence and severity was associated with neuropathy severity, predominant thermal sensory loss, female sex, and nephropathy. Furthermore, it seemed associated with levels of anxiety, depressive symptoms, and pain catastrophizing. They recognized a minority of painful diabetic distal symmetrical sensory-motor polyneuropathy (pDSPN) subjects who exhibited gain quantitative sensory testing (QST) abnormalities. Different sensory profiles could express distinctive pathophysiological mechanisms of NeuP in diabetes and new target populations for future pain trials.