Semi-automated quantification of geographic atrophy with blue-light autofluorescence and spectral-domain optical coherence tomography: A comparison between the region finder and the advanced retinal pigment epithelium tool in the clinical setting
Acta Ophthalmologica Mar 29, 2019
Reumueller A, et al. - Using 2 routinely available quantification tools, based on blue-light fundus autofluorescence (BAF) and spectral-domain optical coherence tomography (SD-OCT), researchers examined inter- vs intraobserver reliability and intermodality agreement on quantification of geographic atrophy. Despite both algorithms requiring frequent adjustment by users, they reported equal reliability and reproducibility of semi-automated analysis of geographic atrophy with Region Finder (RF) and advanced retinal pigment epithelium tool (ARPET) in clinical settings. They observed restriction of size measurements to the central 5 mm in the ARPET limiting its ability to fully track GA progression. They implied that outcomes of both tools were not interchangeable as measurements with ARPET resulted in larger lesion sizes.
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