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Seizures and outcome one year after neonatal and childhood cerebral sinovenous thrombosis

Pediatric Neurology Oct 27, 2019

Mineyko A, Kirton A, Billinghurst L, et al. - Individuals with cerebral sinovenous thrombosis (CSVT, a treatable cause of brain injury, acute symptomatic seizures and remote epilepsy; n = 24) were prospectively recruited from 21 international sites through the Seizures in Pediatric Stroke Study in order to examine epilepsy and neurologic outcomes in neonates and children one year following CSVT diagnosis. The most prevalent presenting symptom in non-neonates was Headache. Nine showed up with acute symptomatic seizures. By 1-year follow-up, six acquired epilepsy. No clinical predictors related to epilepsy were recognized. In 71%, King’s Outcome Scale of Childhood Head Injury and modified Rankin score scores at 1 year were favorable. Half of CSVT cases who acquired epilepsy did not have infarcts, hemorrhage, or seizures determined during the acute hospitalization. In conclusion, this study gives a prospective estimation that by one year following diagnosis of CSVT, epilepsy happens in nearly one-quarter of individuals. Later epilepsy can emerge in the absence of acute seizures or parenchymal injury related to the CSVT.
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