Furuta Y, et al. - Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack (TIA) were explored in a general Japanese population. Researchers followed two cohorts consisting of stroke-free Japanese individuals aged ≥40 years in 1961 (n = 1,621) and in 1988 (n = 2,646) for 24 years. Outcomes indicated a decrease in the incidence of TIA during the past half-century. This decrease may be due to the spread of antihypertensive treatments in the general Japanese population. While those who experienced TIA had a 7-8 fold higher risk in the 10-year incidence of total and ischemic strokes vs those without, no significant change in the impact of TIA on the subsequent risks of stroke was seen between sub-cohorts.