Secular trends in incidence, modality and mortality with dialysis receiving AKI in children in Ontario: A population-based cohort study
Clinical Journal of the American Society of Nephrology Sep 13, 2019
Chanchlani R, Nash DM, McArthur E, et al. - Researchers undertook this investigation in Ontario, Canada to gauge shifts in the incidence of dialysis-receiving AKI among children for a duration of 20 years. In a pediatric population with dialysis-receiving AKI, they analyzed temporal trends in the use of different dialysis modalities and 30-day mortality. Using healthcare administrative databases, they identified all children (29 days to 18 years) who received their first dialysis for AKI between 1996 and 2015, excluding those who received dialysis for ESKD, inborn errors of metabolism, and poisonings. Among hospitalized children, the incidence of dialysis-receiving AKI rose significantly from 1996 (0.58 per 1000 person-years) to 2015 (0.65 per 1000 person-years). A rise in the use of continuous kidney replacement therapy and intermittent hemodialysis was also reported, whereas reduction was noted over time in the relative use of peritoneal dialysis. They also observed an increase in 30-day mortality rates after dialysis-receiving AKI, from 14% to 25% between 1996 and 2009, and these rates declined to 19% in the more recent years.
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