Miyake S, Ashikari K, Kato S, et al. - Since gastrointestinal endoscopy (GIE) is considered a high‐risk procedure in the coronavirus disease 2019 (COVID‐19) pandemic era, researchers conducted this single‐center cross‐sectional study to explore the rate of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) positivity in saliva and gastrointestinal fluids to which endoscopy medical staff are exposed. All patients who underwent GIE at Yokohama City University Hospital were registered from June 1 to July 31, 2020. In total, 783 samples (560 upper GIE and 223 lower GIE samples) were analyzed. No substantial differences were observed between polymerase chain reaction (PCR) positive and PCR negative cases in terms of age, gender, endoscopy intent, medication, or rate of antibody test positivity. Asymptomatic patients had SARS‐CoV‐2 in their gastrointestinal tract, even those with no detectable virus in their saliva. PCR on saliva samples did not show any positive results in either upper or lower GIE samples, but 2.0% of gastrointestinal fluid samples tested positive for SARS‐CoV‐2. When performing procedures, endoscopy medical practitioners should be conscious of infection.