Sarcopenia, but not frailty predicts early mortality and adverse events after emergent surgery for metastatic disease of the spine
The Spine Journal Oct 09, 2019
Bourassa-Moreau E, Versteeg A, Moskven E, et al. - Via a single-institution, retrospective cohort study of 108 individuals who underwent urgent surgery for spinal metastases from 2009 to 2015, researchers examined the ability of frailty and sarcopenia to independently prognosticate early mortality and adverse events (AE's) after urgent surgery for metastatic disease of the spine. At least one acute AE was noted in 85% of individuals. The occurrence of at least one postop AE was prognosticated by sarcopenia. Sarcopenia L3 Total Psoas Area/Vertebral body Area (L3-TPA/VB) and the degree of neurological impairment were predictive of postoperative AE, however, modified Frailty Index or Metastatic Frailty Index, were not. Irrespective of primary tumor type, sarcopenia prognosticated 3-month mortality. Kaplan-Meyer analysis exhibited L3-TPA/VB and the Bollen Scale to considerably distinguish patient survival. Hence, in patients undergoing urgent surgery for spinal metastasis, sarcopenia, efficiently estimated by the L3-TPA/VB on conventional CT, was concluded to prognosticate both early postoperative mortality and adverse events, therefore, in this heterogeneous patient population, presenting a practical tool for timely therapeutic decision-making.
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