Sarcopenia as independent risk factor of postpneumonectomy respiratory failure, ARDS and mortality
Lung Cancer Oct 21, 2020
Martini K, Chassagnon G, Fournel L, et al. - Given the correlation between sarcopenia and poor outcome in cancer-patients, researchers assessed several morphometric measurements of sarcopenia and their prognostic value in short-term-outcome prediction after pneumonectomy. Among 234 patients with pneumonectomy (right, n = 107; left, n = 127), the following CT-based parameters were measured at the level of the third lumbar vertebra to assess sarcopenia: cross-sectional Total Psoas Area (TPA), cross-sectional Total Muscle Area (TMA), and Total Parietal Muscle Area, described as TMA without TPA. TMA was noted to be the best discriminating parameter after excluding fat, though all parameters defining sarcopenia provided significant results. While there were independent associations of right sided pneumonectomy and sarcopenia with the three short-term outcome parameters (Acute Respiratory Failure [ARF], Acute Respiratory Distress Syndrome, and 30-day mortality), Charlson Comorbidity Index had independent predictive value only for ARF.
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