Elbers JBW, et al. - In this systematic review and meta-analysis, researchers analyzed clinical outcomes following salvage surgery for recurrent advanced stage head and neck squamous cell carcinoma (HNSCC) after primary radiotherapy or chemoradiation. They presented the outcome for larynx, hypopharynx, larynx and hypopharynx combined or separately, oral cavity, oropharynx and multiple subsites combined. Complications like fistulas (33%), wound infections (24%) and flap failure (3%) were reported. They recorded only 1% of treatment-related mortality rate and mean hospital stay of 23 days. They preferred salvage surgery for recurrent advanced stage HNSCC after primary chemo/radiotherapy as a last choice of curative treatment, with 37% overall survival at 5 years.