Rivière E, Pascaud J, Tchitchek N, et al. - Researchers examined the interactions between salivary gland epithelial cells (SGECs) from patients with primary Sjögren's syndrome (pSS) or controls and B lymphocytes. An upregulation of interferon signalling pathway and genes implicated in immune responses in pSS were revealed by gene expression analysis of SGECs. Findings showed that a better ability to induce survival and activation of B lymphocytes was demonstrated by SGECs from patients with pSS vs those from controls. This impact was not inhibited by targeting a single cytokine, whereas B-lymphocyte viability in this model was partially reduced by leflunomide, Bruton's tyrosine kinase or phosphatidyl-inositol 3-kinase inhibitors. This offers indications for future treatment choices in pSS.