Hao W, Li N, Mi C, et al. - This study’s findings demonstrate that salidroside exerts a protective effect against diabetes-induced cardiac dysfunction by modulating the mTOR and AMPK signaling pathways. T

• The cardiac functions of diabetic rats were improved by salidroside treatment.

• The results showed that salidroside therapy attenuated the cardiac oxidative stress induced by diabetes.

• In diabetic rat hearts, salidroside inhibited diabetes-induced inflammation.

• Salidroside also alleviated the apoptosis of cardiomyocytes.

• The phosphorylation levels of AMPK, ACC, TSC2, and RAPTOR were also upregulated by the treatment of salidroside.