Mataftsi A, Dermenoudi M, Matsou A, et al. - In this prospective, comparative case-control series involving 100 patients (100), of which 2 were lost to follow-up, researchers contrasted safety of wound hydration to anterior chamber air tamponade for securing watertight closure of clear corneal incisions, during uneventful cataract surgery. At the end of the procedure, patients undergoing phacoemulsification were assigned either to receive an anterior chamber air bubble (Group A) or intrastromal wound hydration with a balanced salt solution (Group B). In terms of preoperative risk factor assessment, baseline central corneal thickness, preoperative endothelial cell density, as well as cumulative dissipated energy and duration of phacoemulsification, the two groups were comparable. In terms of preserving endothelial cell density and function, wound sealing with intrastromal hydration proved to be safer compared with air tamponade.