Fintelmann FJ, et al. - Researchers evaluated safety and tissue adequacy for molecular profiling among repeat postprogression percutaneous transthoracic needle aspirations and biopsies (rebiopsies) in patients with lung cancer with epidermal growth factor receptor (EGFR) mutations. They reviewed all lung biopsies performed at their hospital from 2009 to 2017. Throughout the study duration, 107 rebiopsies and 2,635 lung biopsies were performed in 75 EGFR-mutant patients and in 2,347 patients for other indications, respectively, by nine thoracic radiologists. Computed tomography guidance, coaxial technique, and rapid on-site pathologic evaluation (ROSE) were used to perform all biopsies. They found that compared to typical lung biopsies, less complications were reported in relation to repeat lung biopsies for postprogression molecular profiling of EGFR-mutant lung cancers. Excellent specimen adequacy resulted from coaxial technique, fine-needle aspirates, ROSE, and multiple 20-gauge tissue cores.