Nogueira RG, et al. - This study was performed to ascertain whether the novel 3-dimensional (3-D) stent retriever used in conjunction with an aspiration-based mechanical thrombectomy device (Penumbra System; Penumbra) was noninferior to aspiration-based thrombectomy alone in acute ischemic stroke (AIS). Here, the researchers provided class 1 evidence for the noninferiority of the 3-D stent retriever with aspiration compared to aspiration alone in AIS.