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Sacral neuromodulation in patients with refractory overactive bladder symptoms after failed botulinum toxin therapy: Results in a large cohort of patients

Neurourology and Urodynamics Apr 14, 2021

Reekmans M, Janssen JMW, Vrijens DMJ, et al. - This study was carried out to assess the success rate of sacral neuromodulation (SNM) in patients who received prior therapy with Botulinum toxin A (BoNT‐A) injections. Researchers included a total of 263 individuals with overactive bladder (OAB) symptoms referred for SNM between 2006 and 2019. They compared the success rate of SNM in patients who received prior BoNT‐A with BoNT‐A naive patients. They included a sum of 263 patients who had undergone SNM test stimulation, of which 75 (16 male/57 female) received prior BoNT‐A and 188 (46 male/142 female) were BoNT‐A naive. It was shown that SNM in patients with refractory OAB who failed prior to BoNT‐A is an excellent approach. The data exhibited that the number of injections nor the reason for BoNT‐A discontinuation has a predictive value for success with SNM.

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