Isanaka S, Langendorf C, McNeal MM, et al. - Among healthy infants in Niger, rotasiil induced protection against severe rotavirus gastroenteritis (SRVGE) through an extended follow-up period of about 2 years.

• At approximately 6, 10, and 14 weeks of age, infants were administered 3 doses of Rotasiil or placebo.

• In the first year of life, when the disease burden and risk of death are highest, significant protection was induced; the vaccine also induced protection against a changing pattern of rotavirus strains during the 2-year efficacy period.

• The severe consequences of rotavirus infection are expected to be best averted by rotavirus vaccines that are safe, effective, and protective against multiple strains; this seems especially true for resource-limited settings where access to care may be limited.