D’Antonio F, Berghella V, Di Mascio D, et al. - In the present study, the researchers sought to determine the role of progesterone, pessary and cervical cerclage in reducing the risk of preterm birth (PTB) in twin pregnancies and to compare these interventions using pairwise and network meta-analysis. Medline, Embase, CINAHL and Cochrane databases have been explored. Twenty-six studies were involved in the meta-analysis. Cervical pessary, progesterone, and cerclage have no significant effect on the rate of PTB or perinatal morbidity in twins, whether applied to an unselected population of twins or in pregnancies with a short cervix.