Atiquzzaman M, et al. – In this longitudinal analysis, researchers determined the role of NSAIDs in the heightened risk of cardiovascular disease (CVD) in patients with osteoarthritis (OA). This trial was based on linked health administrative data from British Columbia, Canada, and included 7,743 patients with OA and 23,229 age- and sex-matched non-OA controls who were selected from a population-based cohort of 720,055 British Columbians. A higher risk of CVD was observed in patients with OA vs non-OA controls. The adjusted HR—after accounting for socioeconomic status, BMI, hypertension, diabetes, hyperlipidemia, chronic obstructive pulmonary disease, and Romano comorbidity score—was estimated to be 1.23. For congestive heart failure, the estimated adjusted HRs were 1.42 (95% CI: 1.33–1.51), for ischemic heart disease and for stroke, these values were 1.17 (95% CI: 1.10–1.26) and 1.14 (95% CI: 1.07–1.22), respectively. This was the first-ever study on the mediating role of NSAIDs in the link between OA and CVD. Findings highlighted a substantial role of NSAID use in the OA–CVD association.