Costa V, El‐Achkar VN, de Barros PP, et al. - The prevalence of the Epstein‐Barr virus (EBV) and its correlation with human papilloma virus (HPV) detection, clinicopathological features, and the severity of recurrent respiratory papillomatosis (RRP) were investigated. Based on the Derkay score, 36 cases of juvenile recurrent respiratory papillomatosis and 44 adults with recurrent respiratory papillomatosis were subdivided into low‐ and high‐risk severity groups. HPV was detected in all samples, including 49 cases of HPV 6, 26 cases of HPV 11, four cases of HPV 6 and 11 coinfections, and one case of HPV 16. PCR led to identification of EBV‐DNA in nine samples, although none of the cases were positive by means of in situ hybridization. Per findings, the presence of EBV appears to have no important role in the progression/severity of RRP.