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Role of Doppler ultrasound at time of diagnosis of late‐onset fetal growth restriction in predicting adverse perinatal outcome: Prospective cohort study

Ultrasound in Obstetrics & Gynecology Jun 01, 2020

Rizzo G, Mappa I, Bitsadze V, et al. - Researchers investigated the strength of link between fetoplacental Doppler indices at the time of diagnosis of late‐onset fetal growth restriction (FGR) and adverse perinatal outcome. In addition, they investigated their predictive accuracy. A prospective study was performed of 243 consecutive singleton pregnancies that were complicated by late‐onset FGR. They defined late‐onset FGR as estimated fetal weight (EFW) or abdominal circumference (AC) < 3rd centile, or EFW or AC < 10th centile and umbilical artery (UA) pulsatility index (PI) > 95th centile or cerebroplacental ratio (CPR) < 5th centile, diagnosed after 32 weeks. In 32.5% (95% CI, 26.7–38.8%) of cases, composite adverse perinatal outcome occurred, which was defined as the occurrence of at least one of emergency Cesarean section for fetal distress, 5‐min Apgar score < 7, umbilical artery pH < 7.10 and neonatal admission to the special care unit). Observations revealed independent association of CPR and uterine artery PI assessed at the time of diagnosis with composite adverse perinatal outcome in pregnancies complicated by late‐onset FGR, however, their diagnostic performance is low for composite adverse perinatal outcome. Better accuracy was noted with umbilical vein blood flow normalized for fetal abdominal circumference (UVBF/AC) for prediction of composite adverse perinatal outcome, although its utility in clinical practice as a standalone predictor of adverse pregnancy outcome needs further research.

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