Kanaoka K, Okayama S, Terasaki S, et al. - This retrospective nationwide study was conducted to determine how climatic factors could impact the onset of Takotsubo syndrome (TTS) among patients registered in the Japanese Registry of All Cardiac and Vascular Diseases and Diagnosis Procedure Combination (JROAD–DPC) discharge database, between 2012 and 2016. Diagnosis of TTS were made significantly more often in the summer and early autumn. TTS incidence was shown to be associated with higher temperatures; adjusted incidence rate ratios were estimated to be 1.46 and 1.47 for temperatures of 20–25°C and >25°C, respectively. For the the first 2 days following a typhoon landfall, the incidence rate ratio was estimated to be 1.85. Overall, distinct patterns of seasonal variation in TTS incidence were shown in this study, along with a significant correlation of TTS onset with climatic factors, including typhoon landfalls.