Hoshino-Negishi K, et al. - Using the collagen-induced arthritis (CIA) model, researchers assessed the data to illustrate the use of the fractalkine (FKN)/CX3CR1 pathway in joint destruction in rheumatoid arthritis. They observed a significant decline in arthritis and soft x-ray scores with the implement of prophylactic as well as therapeutic treatment, both with anti-mFKN mAb. They also noticed a decrease in plasma levels of cartilage oligomeric matrix protein and matrix metalloproteinase 3 after treatment with anti-mFKN mAb. Inhibition of synovitis, pannus formation, and cartilage destruction, as well as suppressed bone damage, with a marked reduction in the number of tartrate-resistant acid phosphatase–positive osteoclasts were recorded in the histologic analysis.