Rodgers H, et al. - In this multicenter randomized controlled trial, researchers compared the clinical efficacy of robot-assisted training with the MIT-Manus robotic gym vs an enhanced upper limb therapy (EULT) program based on repetitive functional task practice vs usual care. Seven hundred seventy participants were enrolled and randomly assigned to either robot-assisted training (n=257), EULT (n=259), or usual care (n=254) between April 14, 2014, and April 30, 2018. For patients with moderate or severe upper limb functional limitation, robot-assisted training and EULT did not improve upper limb function after stroke vs usual care. These outcomes as seen in this trial do not support the use in routine clinical practice of robot-assisted training.