Deveaux AE, Allen TA, Al Abo M, et al. - To explore the molecular landscape of lung cancer in patients of African ancestry as well as to determine the race-related disparities in RNA splicing, researchers undertook this investigation. Between patients of West African and European ancestry, 4,829 differentially spliced genes (DSGs) and 267 differentially expressed genes (DEGs) in biobanked lung squamous cell carcinoma (LUSC) were identified. They used the National Cancer Institute Genomic Data Commons to independently validate DSGs and DEGs. Within 3 DSGs as well as 1 DEG, RNA splicing events were validated in the independent cohort. Metabolic process, biological regulation, and multicellular organismal process were identified as the biological processes enriched among DSGs and DEGs, as was ion transport among DSGs. A potential link with LUSC patient survival was demonstrated by 355 RNA splicing events within DSGs and 18 DEGs. According to findings, DSGs and DEGs demonstrating potential biological as well as clinical relevance could be capable of driving novel biomarker and therapeutic development to reduce LUSC differences.