Samama CM, Laporte S, Rosencher N, et al. - A international, parallel-group, randomized, double-blind, noninferiority trial was designed to assess the efficacy and safety of rivaroxaban or enoxaparin in nonmajor orthopedic surgery. Researchers randomized adult individuals who underwent lower-limb nonmajor orthopedic surgery who were considered to be at risk for venous thromboembolism on the basis of the investigator’s judgment to receive either rivaroxaban or enoxaparin. They recruited a sum of 3,604 individuals who underwent randomization; 1,809 patients were assigned to receive rivaroxaban, and 1,795 to receive enoxaparin. After nonmajor orthopedic surgery of the lower limbs, rivaroxaban was found to be a more effective than enoxaparin in the prevention of venous thromboembolic events during a period of immobilization.