Bright CJ, et al. - In this large-scale population-based study consisting of 200,945 survivors of cancer that was diagnosed between ages 15–39 years in England and Wales, researchers assessed the risk of specific subsequent primary neoplasms following 16 types of adolescent and young adult (AYA) cancer. Increases were noted in the excess number of subsequent primary neoplasms observed in association with increased period of follow-up from diagnosis after each AYA cancer investigated. High proportions of the total excess number of neoplasms, attributed to only a small number of specific subsequent primary neoplasms, were reported in patients who had survived at least 30 years from diagnosis of cervical cancer, testicular cancer, Hodgkin lymphoma, and breast cancer. The excess number of neoplasms accounted for by lung cancer was significant and evident across all AYA cancers investigated. In potentially irradiated sites, the occurrence of subsequent primary neoplasms was noted.