Bakhriansyah M, et al. - In this matched case-control study, researchers evaluated the risk of nephrotic syndrome related to NSAID (nonsteroidal anti-inflammatory drug) use. They included patients with a first diagnosis of nephrotic syndrome (cases; n = 2,620) as well as those without nephrotic syndrome (controls; n = 10,454). They categorized NSAID exposure, based on cyclooxygenase enzyme selectivity and chemical groups, as either current (use at the nephrotic syndrome diagnosis date and corresponding date in the control group), recent, or past use. They used unconditional logistic regression analysis to calculate odds ratios and 95% confidence intervals. A higher risk of nephrotic syndrome was observed in relation to the use of conventional NSAIDs, commencing from at least 2 weeks of exposure, as well as for recent and past exposure up to 2 years prior to the diagnosis of nephrotic syndrome. Acetic acid and propionic acid derivatives mainly seemed to account for this higher risk.