Gil MM, Molina FS, Rodríguez‐fernández M, et al. - The risk of miscarriage linked with chorionic villus sampling (CVS) was examined via performing this retrospective cohort study in eight fetal‐medicine units in Spain, Belgium and Bulgaria. Researchers performed assessment of two populations: first, all singleton pregnancies attending to their first‐trimester assessment in Murcia, Spain, and second, all singleton pregnancies having a CVS following first‐trimester assessment at any of the participating centers. The non‐CVS group comprised 22,250 participants and the CVS group comprised 3,613. The CVS group had miscarriage incidence of 2.1% (77/3,613), which was significantly higher than the 0.9% (207/22,250) in the non‐CVS group. This excess risk is not solely due to the invasive procedure but to some extent the demographic and pregnancy characteristics of the patient undergoing CVS. After accounting for these risk factors and confining the analysis to low‐risk pregnancies, CVS appears to raise the risk of miscarriage nearly three times above the patient’s background‐risk. Although in relative terms, this is a substantial increase, the risk of miscarriage following CVS in pregnancies without risk factors will still remain low and similar to or slightly greater than that of the general population. For instance, if risk of aneuploidy in a woman is 1 in a 1,000 (0.1%), her risk of miscarriage after CVS will raise to 0.3% (0.2% higher).