Gil MM, Molina FS, Rodríguez‐fernández M, et al. - The risk of miscarriage linked with chorionic villus sampling (CVS) was estimated. Researchers conducted a retrospective cohort study in eight fetal‐medicine units in Spain, Belgium and Bulgaria including two populations: first, all singleton pregnancies attending to their first‐trimester assessment in Murcia, Spain (n = 22,250) and second, all singleton pregnancies having a CVS following first‐trimester assessment at any of the participating centers (n = 3,613). Analysis revealed nearly 1% higher risk of miscarriage in women having a CVS than women without CVS; this excess risk is, however, not entirely due to the invasive procedure but to some extent the demographic and pregnancy characteristics of the patient undergoing CVS. CVS appears to raise the risk of miscarriage about three times above the patient’s background‐risk after adjusting for these risk factors and confining the analysis to low‐risk pregnancies. In relative terms, this is a substantial increase but in pregnancies without risk factors, the risk of miscarriage after CVS will still remain low and comparable to or slightly greater than that of the general population. For instance, if a patient has risk of aneuploidy of 1 in a 1,000 (0.1%), an increase in risk of miscarriage to 0.3% (0.2% higher) will occur after CVS.