Byun HK, Chang JS, Im SH, et al. - Researchers investigated the comprehensive risk factors for lymphedema, a serious long-term complication in breast cancer patients post surgery, so that a more informed multidisciplinary treatment decision-making could be done. Treatment-related data were retrospectively obtained from 5,549 breast cancer patients who underwent surgery. Lymphedema developed in 639 patients during a median follow-up of 60 months. As per findings, interaction of trimodality breast cancer treatment factors results in promotion of lymphedema. Lowering in lymphedema risk can be achieved by deintensifying node dissection, chemotherapy regimen, and field and dose of radiotherapy. Lymphedema risk might be minimized by undertaking deescalation strategies on a multidisciplinary basis.