Zarka F, Tayler-Gomez A, Ducruet T, et al. - Researchers undertook this single-center retrospective cohort analysis to determine if acute kidney injury (AKI) is related to an increased risk of bleeding. Exclusion criteria included readmissions, admissions < 24 h, end-stage kidney disease or kidney transplants. The main outcome of interest was the occurrence of incident bleeding assessed via multivariate time-dependent Cox models. Experts removed patients who bled prior to ICU (n = 488) in order to define the predictors of incident bleeding. A trend toward higher risks of bleeding in AKI, and a higher risk of bleeding in AKI-needing dialysis, was noted among 513 bleeding-free patients. The factors that demonstrated a link with bleeding were: cirrhosis, AKI-requiring dialysis, anticoagulation, and coronary artery disease, while SOFA score and sepsis had a protective link. There was no link between incident bleeding and mortality. Overall, AKI-requiring dialysis was shown to be related to incident bleeding, independent of anticoagulant delivery.