Antwi SO, et al. - Among first-degree relatives (FDRs) of unselected pancreatic cancer (PC) probands, researchers determined the risk for 15 cancer types, with a focus on the roles of susceptibility gene mutations. From 2,305 sequential PC probands enrolled at Mayo Clinic (2000-2016), data from 17,162 FDRs (> 336,000 person-years at risk) were identified and analyzed. Comparisons were made for malignancies observed among the FDRs vs that expected using Surveillance, Epidemiology, and End Results (SEER) data. In a subset of probands (n=2,094), genetic testing was performed. Among FDRs of PC patients, twofold risk of PC was evident. Female FDRs were found to have an increased risk for primary liver cancer. Substantially increased risk for PC and increased risk for breast and ovarian cancers were observed in FDRs of susceptibility mutation carriers.