Tsao N, et al. - In this population-based cohort study, women with one or more autoimmune diseases who had pregnancies between January 1st, 2002 and December 31st, 2012 were involved in order to ascertain the relationship between perinatal biologic use and congenital anomalies in women with autoimmune disease. The high dimensional propensity score-matched cohort involved 117 pregnancies (107 women) exposed to biologics and 585 pregnancies (562 women) that were not exposed to biologics during the period of interest. No discernible patterns relative to the congenital anomalies were seen in the biologics exposed group. Secondary and sensitivity analyses did not alter the results appreciably. Thus, these population-based data imply that the use of biologics prior to and during pregnancy is not related to a heightened risk of congenital anomalies.